|
T5383 |
D3-βArr
|
NCGC00379308 |
TSH Receptor
|
|
D3-βArr (NCGC00379308) is a positive allosteric modulator for thyrotropin receptor (TSHR), which initiates translocation of β-Arr 1 (EC50: 11.6 μM) by direct TSHR activation. |
|
T6430L |
Calcifediol monohydrate
|
25-hydroxy Vitamin D3 monohydrate |
Endogenous Metabolite
|
|
Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), the main circulating metabolite of vitamin D3, is a potent VDR inhibitor. |
|
T6374 |
Alfacalcidol
|
Bondiol,Etalpha,1-hydroxy Vitamin D3,1.alpha.-Hydroxyvitamin D3,1-hydroxycholecalciferol |
Others
|
|
Alfacalcidol (Etalpha) (1-hydroxycholecalciferol; Alpha D3; 1.alpha.-Hydroxyvitamin D3) is a non-selective VDR activator medication. |
|
T83776 |
Dopamine D3 Receptor Agonist 13a
|
|
|
|
Dopamine D3 receptor agonist 13a selectively targets the dopamine D3 receptor over dopamine D1, D2, and D4 receptors, with affinities (Ki values) of 0.14, 4,600, 2.85, and 756 nM, respectively. It also interacts with ser... |
|
T62946 |
Dopamine D3 receptor antagonist-2
|
|
|
|
Dopamine D3 receptor antagonist-2 is a dopamine D3 receptor selective (Ki=2.16 nM) or multi-targeting dual ligand that shows potential effects in CNS disorders. |
|
T64024 |
Dopamine D3 receptor antagonist-1
|
|
|
|
Dopamine D3 receptor antagonist-1 is a dopamine D3 receptor selective or multi-targeting ligand with a Ki value of 1.58 nM that has demonstrated therapeutic potential for central nervous system disorders. |
|
T62528 |
Dopamine D3 receptor ligand-1
|
|
|
|
Dopamine D 3 receptor ligand is a potent, selective, high-affinity dopamine D3 receptor ligand that is 89 times more selective for D3 (Ki: 8 nM) than D2 (Ki: 715 nM). |
|
T21667 |
FAUC-365
|
FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro-
phenyl)-piperazin-1-yl]-butyl}-amide,FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro- phenyl)-piperazin-1-yl]-butyl}-amide |
Dopamine Receptor
|
|
FAUC-365 is a D3 dopamine receptor agonist. |
|
T3431 |
Pardoprunox hydrochloride
|
SLV-308 hydrochloride,DU-126891 hydrochloride |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
|
|
Pardoprunox hydrochloride (SLV-308 hydrochloride) is a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist, D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist and 5-HT1A recept... |
|
T7553 |
(+)-PD 128907 hydrochloride
|
|
Dopamine Receptor
|
|
(+)-PD 128907 hydrochloride is an agonist of D3 dopamine receptor . |
|
T23143 |
PG 01037 dihydrochloride
|
PG-01037 2HCl |
Dopamine Receptor
|
|
PG 01037 dihydrochloride (PG-01037 2HCl) is a potent and selective dopamine D3 receptor antagonist with a Ki of 0.7 nM. |
|
T10213 |
A-437203
|
ABT-925,A37203,Lu201640 |
Dopamine Receptor
|
|
A-437203 (Lu201640) is A kind of based on 1 h - pyrimidin - 2 - one sca ff old, selective, new powerful d3 receptor antagonist, on D2, d3, and D4 receptor, Ki value 71, respectively 1.6 and 6220 nM. |
|
T12861 |
SB-277011
|
SB-277011A |
Dopamine Receptor
|
|
SB-277011 (SB-277011A) is a specific antagonist of the dopamine D3 receptor with pKi values of 8.0, 6.0, 5.0, and <5.2 for D3 receptor, D2 receptor, 5-HT1D, and 5-HT1B respectively. |
|
T6142 |
PD128907 HCl
|
|
Dopamine Receptor
|
|
PD128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor. |
|
T4577 |
Cariprazine
|
RGH-188 |
Dopamine Receptor
,
5-HT Receptor
|
|
Cariprazine (RGH-188) is a novel antipsychotic drug candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki=2.6 nM). |
|
T8382 |
Cariprazine hydrochloride
|
Cariprazine HCl,RGH188 hydrochloride |
Dopamine Receptor
,
5-HT Receptor
|
|
Cariprazine hydrochloride (RGH188 hydrochloride) is an antipsychotic drug, is a D3 and D2 receptor partial agonist((Ki of 0.085 nM and 0.49 nM, respectively) |
|
T11799 |
L-745870 hydrochloride
|
|
Dopamine Receptor
|
|
L-745870 hydrochloride has excellent brain penetration. L-745870 hydrochloride is a high-affinity, selective and orally active human dopamine D4 receptor antagonist with a Ki of 0.43 nM, and considerably weaker D2 recept... |
|
T24797 |
SK609 HCl
|
SK-609 HCl,SK609 hydrochloride,SK 609 HCl,SK 609 hydrochloride,SK-609 hydrochloride |
|
|
SK609 HCl is a selective dopamine D3 receptor agonist. It also has atypical signaling properties. |
|
T7635 |
Raclopride
|
|
Dopamine Receptor
|
|
Raclopride is a selective antagonist of dopamine D2/D3 receptor. |
|
T23167 |
PNU-177864
|
|
Dopamine Receptor
|
|
PNU-177864 is a selective dopamine D3 receptor antagonist. |
|
T9409 |
Mesdopetam hemitartrate
|
IRL790 hemitartrate,1-Propanamine, N-[2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethyl]-, (2R,3R)-2,3-dihydroxybutanedioate (2:1) |
Dopamine Receptor
|
|
Mesdopetam hemitartrate (IRL790 hemitartrate) is an antagonist of dopamine D3 receptor (Ki=90 nM; IC50=9.8 μM for human recombinant D3 receptor). It has psychomotor stabilizing properties. |
|
T70302 |
Fallypride
|
|
Dopamine Receptor
|
|
Fallypride is a potent and selective dopamine D2/D3 receptor antagonist. |
|
T22817 |
GSK 789472 hydrochloride
|
GSK-789472 HCl,1-phenyl-3-(piperidin-2-ylmethyl)imidazolidin-2-one hydrochloride,4,5-Dihydro-1-phenyl-3-(2-piperidinyl)methylimidazol-2(1H)-one |
Dopamine Receptor
|
|
GSK 789472 hydrochloride is both a dopamine D3 receptor antagonist and a D2 partial agonist. |
|
T11463 |
GR 103691
|
|
Dopamine Receptor
|
|
GR 103691 is a potent, selective dopamine D3 receptor antagonist (Ki: 0.4 nM). It shows more than 100-fold selectivity for human dopamine human (h)D3 over hD4 and hD1 sites. |
|
T4007 |
Eticlopride hydrochloride
|
|
Dopamine Receptor
|
|
Eticlopride, an antipsychotic, is a Selective dopamine D2/D3 receptor antagonist (Ki: 0.5/0.16 nM). |
|
T60835 |
SKF83959
|
|
Dopamine Receptor
|
|
SKF83959, a benzazepine analog, is a selective and potent partial agonist of the dopamine D1 receptor with Ki values of 1.18, 7.56, 920, and 399 nM for rat D1, D5, D2, and D3 receptors, respectively.SKF83959 is a potent ... |
|
T14767 |
BP 897 hydrochloride
|
|
Dopamine Receptor
|
|
BP 897 is a potent and selective agonist of dopamine D3 receptor and it is a weak dopamine D2 receptor antagonist, with Kis of 0.92 nM and 61 nM for D3 and D2 receptors. Which shows low affinities at D1 and D4 receptors ... |
|
T38754 |
Trazpiroben
|
TAK-906 |
Dopamine Receptor
|
|
Trazpiroben (TAK-906) is a selective dopamine D2/D3 receptor antagonist used in the study of gastroparesis. |
|
T7180 |
Sultopride hydrochloride
|
LIN-1418 hydrochloride |
Dopamine Receptor
|
|
Sultopride hydrochloride (LIN-1418 hydrochloride) is a selective dopamine D2 and D3 receptor antagonist. |
|
TQ0244 |
Calcipotriol monohydrate
|
|
|
|
|
|
T9100 |
BP 897
|
2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]- |
Dopamine Receptor
|
|
BP 897 (2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-) is a potent and selective dopamine D3 receptor agonist, and a weak dopamine D2 receptor antagonist, with Kis of 0.92 nM and 61 nM for D3 ... |
|
T21446 |
Rotigotine Hydrochloride
|
Rotigotine (Hydrochloride),N 0923,N-0924,Rotigotine HCl,N-0923 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
|
|
Rotigotine Hydrochloride (N-0924), a dopamine receptor agonist prefering for D3 receptors over D1 and D2, has effective activity of anti-Parkinsonian. Racemic rotigotine hydrochloride is about 50 times as potent as quinp... |
|
T28167 |
NGB 2904
|
NGB2904 HCl,NGB-2904,NGB2904 |
Others
,
Dopamine Receptor
,
5-HT Receptor
|
|
NGB 2904 is a potent and selective antagonist of dopamine D3 receptor (Ki values are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D3, D2, 5-HT2, α1, D4, D1 and D5 receptors respectively). NGB2904 potently antag... |
|
T15117 |
Didesmethyl cariprazine
|
|
Dopamine Receptor
,
5-HT Receptor
|
|
Didesmethyl cariprazine, a metabolite of Cariprazine, is the major cyclic active part. Didesmethyl cariprazine has a long half-life of 1-3 weeks. Cariprazine is a potent D3 preference D3/D2 receptor partial agonist of do... |
|
T26375 |
(S)-Amisulpride
|
Esamisulpride,(S) Amisulpride,SEP-4199 |
Dopamine Receptor
,
5-HT Receptor
|
|
(S)-Amisulpride ((S) Amisulpride) (Esamisulpride) is a potent dopamine D2/D3 receptor antagonist. (S)-Amisulpride is an antagonist at the 5-HT7 receptor with a Ki of 900 nM. (S)-Amisulpride has antipsychotic and antidepr... |
|
T22904 |
L-745870 trihydrochloride
|
L-745,870 trihydrochloride |
Dopamine Receptor
,
Sigma receptor
,
5-HT Receptor
,
Adrenergic Receptor
|
|
L-745870 trihydrochloride is a highly potent and selective D4 dopamine receptor antagonist. |
|
T23066 |
NGD 94-1
|
|
Dopamine Receptor
|
|
NGD 94-1 is a selective D4 receptor antagonist with an affinity of 3 nM for the D4 receptor and greater than 2 pM for the D1, D2, D3, and D5 receptors.NGD 94-1 can be used in the study of cognitive disorders and other ps... |
|
T24055 |
FAUC 213
|
FAUC213,FAUC-213 |
Dopamine Receptor
|
|
FAUC 213 is a selective full antagonist of the dopamine D4 receptor. |
|
T70044 |
Sarizotan HCl
|
|
|
|
Sarizotan, also known as EMD-128130, is a Dopamine D2 receptor partial agonist and Serotonin 1A receptor agonist. Sarizotan exhibits affinity at serotonin and dopamine receptors. Sarizotan effectively suppresses levodopa... |
|
T12510 |
PNU-177864 hydrochloride
|
PNU-177864 (hydrochloride) |
Dopamine Receptor
|
|
|
|
T30098 |
Aplindore Fumarate
|
Aplindore,DAB-452 Fumarate,DAB-452 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
|
|
Aplindore Fumarate (DAB-452) is a small molecule dopamine D2 receptor partial agonist.Aplindore Fumarate exhibits high affinity for dopamine D2 and D3 receptors, and low affinity for dopamine D4, 5-hydroxytryptophan (5-H... |
|
T67913 |
(-)-GSK598809 hydrochloride
|
|
|
|
(-)-GSK598809 hydrochloride is the isomer of GSK598809. GSK598809 is a selective antagonist of the dopamine D3 receptor (DRD3), which is a neural response that selectively enhances reward anticipation in drug and alcohol... |
|
TQ0311 |
GSK163090
|
|
Dopamine Receptor
,
5-HT Receptor
|
|
GSK163090 is a specific and orally active 5-HT1A/B/D receptor antagonist (pKis: 9.4/8.5/9.7, and 6.3/6.7 for 5-HT1A/B/D, and dopamine D2/D3). |
|
T3187 |
Fluoroclebopride
|
|
Dopamine Receptor
|
|
Fluoroclebopride is a dopamine (DA) D2 receptor ligand. |
|
T1476 |
Pramipexole
|
SND 919 |
Dopamine Receptor
|
|
Pramipexole (SND 919) is a selective dopamine receptor agonist used in the therapy of Parkinson disease. Pramipexole therapy is associated with a low rate of transient serum enzyme elevations during treatment but has not... |
|
T10249 |
Adoprazine
|
SLV313 |
Others
|
|
Adoprazine (SLV313) is a potential atypical antipsychotic bearing potent D2 receptor antagonist and 5-HT1A receptor agonist properties. |
|
T5397 |
A-381393
|
|
Dopamine Receptor
|
|
A-381393 is a selective and brain penetrate dopamine D4 receptor antagonist (Kis: 1.9/1.5/1.6 nM for human dopamine D4.2/D4.4/D4.7 receptor). |
|
T7834 |
ABT-724
|
|
Dopamine Receptor
|
|
ABT-724 is an agonist of dopamine D4 receptor(EC50: 12.4 nM) |
|
T37816 |
SB 243213
|
|
|
|
SB 243213 is an orally active, selective and high-affinity 5-HT2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 shows greater than a 100-fold selectivity over a wide range o... |
|
T1539 |
Iloperidone
|
HP 873 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
|
|
Iloperidone (HP 873) is an atypical antipsychotic agent that is used for treatment of schizophrenia. |
